FKBP4 monoclonal antibody, clone Hi52C (ATTO 390)
* The price is valid only in USA. Please select country.
- More Files
Application Data with Unconjugated Antibody
Immunohistochemistry
Immunohistochemical staining of human prostate tissue with FKBP4 monoclonal antibody, clone Hi52C (Cat # MAB11372) shows the strongest staining for FKBP4 is in ductal epithelial cells.
- Specifications
Product Description
Mouse monoclonal antibody raised against synthetic peptide of FKBP4.
Immunogen
A synthetic peptide corresponding to residues of human FKBP4.
Host
Mouse
Reactivity
Dog, Hamster, Human, Mouse, Rat
Form
Liquid
Conjugation
ATTO 390
Extinction Coefficient
24,000
Excitation (Max)
390 nm
Emission (Max)
479 nm
Purification
Protein G purification
Isotype
IgG
Recommend Usage
Western Blot (1:2000)
Immunohistochemistry (1:250)
Immunoprecipitation (5 ug with 10-20 uL Protein A beads)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
Application Data with Unconjugated Antibody
Immunohistochemistry
Immunohistochemical staining of human prostate tissue with FKBP4 monoclonal antibody, clone Hi52C (Cat # MAB11372) shows the strongest staining for FKBP4 is in ductal epithelial cells.
- Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
- Gene Info — FKBP4
Entrez GeneID
2288Protein Accession#
NP_002005.1Gene Name
FKBP4
Gene Alias
FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
Gene Description
FK506 binding protein 4, 59kDa
Omim ID
600611Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq
Other Designations
52 kD FK506 binding protein|FK506 binding protein 4 (59kD)|FK506 binding protein 52|FK506-binding protein 4 (59kD)|HSP binding immunophilin|T-cell FK506-binding protein, 59kD|p59 protein|peptidylprolyl cis-trans isomerase|rotamase
- Interactomes
- Diseases