Forskolin
Referência M2191-10mg
Tamanho : 10mg
Marca : AbMole Bioscience
All AbMole products are for research use only, cannot be used for human consumption.

Coleonol; Colforsin; HL 362
Quality Control & Documentation
Biological Activity
Forskolin (also called Coleonol) is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). Forskolin is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin can activate or upregulate the proliferation of Schwann cells in culture, together with Fibroblast growth factor or Transforming Growth Factor-Beta. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.
Product Citations
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Cancer Lett. 2024 Oct 02;605:217284.
Exploring epigenetic dynamics unveils a super-enhancer-mediated NDRG1-β-catenin axis in modulating gemcitabine resistance in pancreatic cancer
Forskolin purchased from AbMole -
Biochem Pharmacol . 2023 Jan;207:115355.
Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease
Forskolin purchased from AbMole -
Biochem Pharmacol. 2022 Nov 25;115355.
Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease
Forskolin purchased from AbMole -
Acta Histochem. 2022 Aug;124(6):151931.
Fibroblast-derived exosomal miRNA-133 promotes cardiomyocyte-like differentiation
Forskolin purchased from AbMole -
Biochem Biophys Res Commun. 2020 Apr 30;525(2):326-333.
Spexin as an Anxiety Regulator in Mouse Hippocampus: Mechanisms for Transcriptional Regulation of Spexin Gene Expression by Corticotropin Releasing Factor
Forskolin purchased from AbMole
Chemical Information
Molecular Weight | 410.51 |
Formula | C22H34O7 |
CAS Number | 66575-29-9 |
Solubility (25°C) | DMSO 50 mg/mL Ethanol 20 mg/mL |
Storage | 2-8°C, protect from light |
References
[1] Godard MP, et al. Obes Res. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.
[2] Kim SS, et al. Neuroreport. cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK.
[3] Insel PA, et al. Cell Mol Neurobiol. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.