A1138-1mg | Glycoprotein B (485-492) Clinisciences

Background

Glycoprotein B (485-492), (C41H67N11O13), a peptide with the sequence H2N-Ser-Ser-Ile-Glu-Phe-Ala-Arg-Leu-OH, MW= 922.04. glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus (HSV). Herpesviruses have an envelope and an outer lipid bilayer which contains twelve surface glycoproteins. For infectivity to be attained, the double stranded DNA genome of HSV must enter the host cell through means of fusion of its envelope with the cellular membrane or via endocytosis(1). The herpesvirus glycoprotein B is the most highly conserved of all surface glycoproteins and acts primarily as a fusion protein. The precise functions of gB and gH/gL are unknown but they are required for viral entry into the cell and constitute the core fusion machinery. The claim that gB is involved in fusion comes from the notable syncytial phenotype caused by certain mutations within the cytoplasmic domain of glycoprotein B(2), as well as its strucutral homology to other viral fusion proteins(3).

A1138_1

Figure1 the structures of Glycoprotein B

A1138_2

Figure 2 mechanism of virus into cells

Ref:

1. PereiraL, Ali M, Kousoulas K, Huo B, Banks T (September 1989). "Domain structure of herpes simplex virus 1 glycoprotein B: neutralizing epitopes map in regions of continuous and discontinuous residues". Virology 172 (1): 11–24.

2. Bender FC, Samanta M, Heldwein EE, de Leon MP, Bilman E, Lou H, Whitbeck JC, Eisenberg RJ, Cohen GH (April 2007). "Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions". J. Virol. 81 (8): 3827–41.

3. Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC (July 2006). "Crystalstructure of glycoprotein B from herpes simplex virus 1". Science 313 (5784): 217–20.

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	922.04
Formula	C₄₁H₆₇N₁₁O₁₃
Synonyms	H2N-Ser-Ser-Ile-Glu-Phe-Ala-Arg-Leu-OH
Solubility	≥92.2 mg/mL in DMSO; insoluble in EtOH; ≥12.24 mg/mL in H2O
SDF	Download SDF
Canonical SMILES	NC(CO)C(NC(CO)C(NC(C(CC)C)C(NC(CCC(O)=O)C(NC(CC1=CC=CC=C1)C(NC(C)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 99.61%

Glycoprotein B (485-492)

Referência A1138-1mg

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Background

Chemical Properties

Quality Control