- More Files
Result Data
Result Data
Inhibition of HDAC1 by Trichostatin A. Shown is a typical inhibition curve using this kit. "Veh." Represents compound vehicle control.
- Specifications
Product Description
HDAC1 Inhibitor Screening Assay Kit is a fluorescence-based method for screening HDAC1 inhibitors.
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at -80°C temporarily. For best results, store the components as described in the protocol.
Note
Result Data
- Applications
Functional Study
- Gene Info — HDAC1
Entrez GeneID
3065Gene Name
HDAC1
Gene Alias
DKFZp686H12203, GON-10, HD1, RPD3, RPD3L1
Gene Description
histone deacetylase 1
Omim ID
601241Gene Ontology
HyperlinkGene Summary
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq
Other Designations
OTTHUMP00000008745|reduced potassium dependency, yeast homolog-like 1
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.
Qianqian Qiu, Fanglian Chi, Daoguang Zhou, Zhancheng Xie, Yunxiao Liu, Hanyu Wu, Ziyu Yin, Wei Shi, Hai Qian.
Journal of Medicinal Chemistry 2023 Apr; 66(8):5753.
Application：Func, Chemical, Chemical.
- Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.