Iadademstat (dihydrochloride) [1431303-72-8]
Referência HY-12782T-10mg
Tamanho : 10mg
Marca : MedChemExpress
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Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.
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Iadademstat dihydrochloride Chemical Structure
CAS No. : 1431303-72-8
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
Other Forms of Iadademstat dihydrochloride:
- Iadademstat Obtenir un devis
| Description |
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. |
IC50 & Target |
KDM1A/LSD1[1] |
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| In Vitro |
Iadademstat dihydrochloride is a KDM1A inhibitor that inactivate KDM1A by irreversible binding to the flavin adenine nucleotide (FAD) cofactor. Iadademstat has very high selectivity for KDM1A over the MAO enzymes, high selectivity over KDM1B and unrivaled subnanomolar cellular activity in differentiation and colony formation assays on mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines. Iadademstat provokes a time and dose-dependent induction of the Cd11b differentiation marker in MLL-AF9 cells, which interestingly preceeds changes in H3K4me2 levels. While MLL-translocated cells are especially sensitive, other acute leukemia (AL) cell lines also respond to Iadademstat[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| In Vivo |
Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Masse moléculaire |
303.27 |
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| Formule |
C15H24Cl2N2 |
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| CAS No. |
1431303-72-8 |
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| Appearance |
Solid |
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| Color |
White to off-white |
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| SMILES |
N[C@@H]1CC[C@@H](N[C@H]2[C@H](C3=CC=CC=C3)C2)CC1.07Cl.07Cl |
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| Livraison | Room temperature in continental US; may vary elsewhere. |
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| Stockage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture) |
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| Solvant et solubilité |
In Vitro:
H2O : 57.75 mg/mL (190.42 mM; Need ultrasonic and warming) DMSO : 0.69 mg/mL (2.28 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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| Pureté et documentation | |||||||||||||
| Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 3.2974 mL | 16.4870 mL | 32.9739 mL | 82.4348 mL |
| H2O | 5 mM | 0.6595 mL | 3.2974 mL | 6.5948 mL | 16.4870 mL |
| 10 mM | 0.3297 mL | 1.6487 mL | 3.2974 mL | 8.2435 mL | |
| 15 mM | 0.2198 mL | 1.0991 mL | 2.1983 mL | 5.4957 mL | |
| 20 mM | 0.1649 mL | 0.8243 mL | 1.6487 mL | 4.1217 mL | |
| 25 mM | 0.1319 mL | 0.6595 mL | 1.3190 mL | 3.2974 mL | |
| 30 mM | 0.1099 mL | 0.5496 mL | 1.0991 mL | 2.7478 mL | |
| 40 mM | 0.0824 mL | 0.4122 mL | 0.8243 mL | 2.0609 mL | |
| 50 mM | 0.0659 mL | 0.3297 mL | 0.6595 mL | 1.6487 mL | |
| 60 mM | 0.0550 mL | 0.2748 mL | 0.5496 mL | 1.3739 mL | |
| 80 mM | 0.0412 mL | 0.2061 mL | 0.4122 mL | 1.0304 mL | |
| 100 mM | 0.0330 mL | 0.1649 mL | 0.3297 mL | 0.8243 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.