Mouse Anti-Human FADD-HRP

Referência 10941-05

Tamanho : 1.0mL

Marca : Southern Biotech

Contactar o distribuidor local :


Telefone : +1 850 650 7790

More Information
Clone 1A11
Isotype Mouse (BALB/c) IgG1κ
Isotype Control Mouse IgG1-HRP (15H6)
Specificity Human FADD
Alternative Names FAS-associated death domain protein, GIG3, MGC8528, MORT1
Description Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1β-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
Immunogen Recombinant FADD
Conjugate HRP (Horseradish Peroxidase)
Buffer Formulation 50% Glycerol/50% Phosphate buffered saline, pH 7.4
Clonality Monoclonal
Concentration Lot specific
Volume 1.0 mL
Recommended Storage 2-8°C
Applications ELISA – Quality tested
Western Blot – Quality tested
Immunoprecipitation – Quality tested

RRID Number AB_2794560
Gene ID 8772 (Human)
Gene ID Symbol FADD (Human)
Gene ID Aliases GIG3; MORT1
UniProt ID Q13158 (Human
UniProt Name FADD_HUMAN (Human)
Documentation
Technical Bulletin Safety Datasheet

Certificate of Analysis Lookup

Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view