Rituximab [174722-31-7]
Referência HY-P9913-5mg
Tamanho : 5mg
Marca : MedChemExpress
Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer.
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Rituximab Chemical Structure
CAS No. : 174722-31-7
This product is a controlled substance and not for sale in your territory.
Based on 6 publication(s) in Google Scholar
Other Forms of Rituximab:
- Rituximab (anti-CD20) In-stock
Description |
Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer. |
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Isotype |
Human IgG1 kappa |
Recommend Isotype Controls |
Human IgG1 kappa, Isotype Control |
Species |
Chimeric |
In Vitro |
Rituximab inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab[1]. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab induces high CDC killing of follicular lymphoma cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
In Vivo |
A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
Essai clinique |
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CAS No. |
174722-31-7 |
Appearance |
Liquid |
Color |
Colorless to light yellow |
SMILES |
[Rituximab] |
Livraison | Shipping with dry ice. |
Stockage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
Pureté et documentation |
Purity: 99.85% |
Références |
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Rituximab Related Classifications
- Immunology/Inflammation
- CD20
Calculateur de molarité
Calculateur de dilution
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Rituximab174722-31-7Anti-Human CD20 type I, Chimeric AntibodyCD20Inhibitorinhibitorinhibit