Z-VAD-FMK
Referência M3143-1mg
Tamanho : 1mg
Marca : AbMole Bioscience
All AbMole products are for research use only, cannot be used for human consumption.
Quality Control & Documentation
Biological Activity
Z-VAD-FMK (10 μM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 μM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells.
Product Citations
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Cancer Res. 2024 Jan;0008-5472.
The imipridone ONC213 targets α-ketoglutarate dehydrogenase to induce mitochondrial stress and suppress oxidative phosphorylation in acute myeloid leukemia
Z-VAD-FMK purchased from AbMole -
Biochem Pharmacol. 2024 Feb 17;116065.
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax
Z-VAD-FMK purchased from AbMole -
Toxicol Appl Pharmacol. 2024 Jan;116825.
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing …
Z-VAD-FMK purchased from AbMole -
Leuk Res. 2024 Jun 29;52(1):46.
Combining the novel FLT3 and MERTK dual inhibitor MRX-2843 with venetoclax results in promising antileukemic activity against FLT3-ITD AML
Z-VAD-FMK purchased from AbMole -
Cancer Res. 2023 Jan 18;83(2):251-263.
MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis
Z-VAD-FMK purchased from AbMole -
JACC-BASIC TRANSL SC. 2023 May 31.
PCSK9 Promotes Hypoxia-Induced Endothelial Cell Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia
Z-VAD-FMK purchased from AbMole -
Food Science and Human Wellness. 2023 Jun 1.
3-epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma
Z-VAD-FMK purchased from AbMole -
J Cell Physiol. 2023 Jun 3.
miR-210/NF-κB axis: A new direction for regulating cadmium-induced pig artery inflammatory injury
Z-VAD-FMK purchased from AbMole -
Neoplasma. 2023 Feb 23;221217N1185.
Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia
Z-VAD-FMK purchased from AbMole -
J Cell Mol Med. 2022 May;26(9):2646-2657.
Venetoclax enhances DNA damage induced by XPO1 inhibitors: A novel mechanism underlying the synergistic antileukaemic effect in acute myeloid leukaemia
Z-VAD-FMK purchased from AbMole -
Eur J Surg Oncol. 2022 Feb 19;S0748-7983(22)00114-7..
In desmoid-type fibromatosis cells sorafenib induces ferroptosis and apoptosis, which are enhanced by autophagy inhibition
Z-VAD-FMK purchased from AbMole -
J Hazard Mater. 2021 Mar 15;406:124682.
Regulation of H 2 S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p/TGFBR3 axis and the involvement of oxidative stress in this process
Z-VAD-FMK purchased from AbMole -
Environ Pollut. 2021 Feb 1;270:116051.
Bisphenol AF induces apoptosis via estrogen receptor beta (ERβ) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN
Z-VAD-FMK purchased from AbMole -
Ecotoxicol Environ Saf. 2021 Sep 1;220:112341.
Cadmium induces apoptosis of human granulosa cell line KGN via mitochondrial dysfunction-mediated pathways
Z-VAD-FMK purchased from AbMole -
Ecotoxicol Environ Saf. 2021 Jan 15;208:111429.
Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca 2+-ASK1-JNK pathway in human granulosa cell line KGN
Z-VAD-FMK purchased from AbMole -
Anat Rec (Hoboken). 2020 Jan 21.
Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
Z-VAD-FMK purchased from AbMole
Chemical Information
Molecular Weight | 467.49 |
Formula | C22H30FN3O7 |
CAS Number | 187389-52-2 |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Ilangovan R, et al. J Biol Chem. Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells.
[2] Slee EA, et al. Biochem J. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.