Mesenchymal stromal / stem cells (MSCs) are the leading adult stem cells in clinical trials due to their immune modulatory properties and multipotent differentiation potential to form cartilage, bone and other cell types. However, because MSCs exist in a small population, the ability to expand these progenitor cells in vitro is a limiting step in utilizing MSCs for cell therapy applications. Using our PRIME-XV brand of validated MSC media and reagents, users are able to maximally expand MSCs derived from human bone marrow, adipose tissue and umbilical cord in a serum-free cell culture system. As with many of our other PRIME-XV products, Irvine Scientific's PRIME-XV MSC expansion medium and osteogenic differentiation medium are manufactured under GMP and are designed to meet regulatory requirements.
Human mesenchymal stromal/ stem cell (MSC) expansion serum-free medium
PRIME-XV MSC Expansion SFM (Cat. No. 91135)
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- Outperforms leading competitors and serum-containing media in expansion while maintaining MSC characteristics and multipotency.
- Supports MSCs derived from bone marrow, adipose tissue and umbilical cord.
- Available as a complete, ready-to-use medium.
- Requires little to no adaptation from serum-containing medium.
- Manufactured under cGMP conditions.
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Mesenchymal Stem Cells Attachment Substrates
PRIME-XV MatrIS F (Cat. 31001)
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- Recombinant Human Matrix Protein
- Proprietary attachment substrate for the culture of human stem/progenitor cells under serum-free conditions
- Recombinant human matrix protein to ensure lot-to-lot consistency
- Available in 200 µg lyophilized packaging
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PRIME-XV Human Fibronectin (Cat. 31002)
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- Human Plasma-Derived Fibronectin
- Validated use in a variety of primary cell attachment and spreading applications
- Carrier free
- Available in 1mg packaging
- Processed under cGMP conditions
- Custom packaging available
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Preservation of Mesenchymal Cells
PRIME-XV Hypothermic Preservation Solution (Cat. 31003)
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- Protein-Free, Defined Hypothermic Preservation Solution for Cells and Tissues
- Animal component-free, protein-free solution
- Supports storage and shipping stability for biologics under hypothermic (2–8°C) conditions
- Reduces cellular stress response from chilling and re-warming of cells and tissues
- Provides pH buffering, osmotic/oncotic support and energy substrates to balance intracellular states at low temperatures
- No additional components are needed
- Manufactured under cGMP conditions
- Available in 10 mL packaging
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PRIME-XV Cryogenic Preservation Solution (Cat. 31004)
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- Protein-Free, Defined Cryogenic Preservation Solution for Cells and Tissues
- Animal component-free, protein-free solution
- Enables a variety of cell types to preserve at -80°C to -196°C temperature environments
- Reduces post-preservation necrosis and apoptosis compared to commercial and home-brew isotonic formulations
- No additional components are needed
- Manufactured under cGMP conditions
- Available in 10 mL packaging
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