Abbexa
Abbexa is a dedicated worldwide supplier of biological tools for the life science, pharmaceutical and biotechnology research and development sectors. Abbexa provides the scientific community with primary antibodies, secondary antibodies, proteins, ELISA kits and enzymes as well as other kits and tools designed for use in research. Abbexa also offers custom protein, peptide and antibody production services to meet customer requirements. Abbexa is committed to providing scientists and researchers with the best customer experience and high-quality products. Abbexa’s mission is to offer unrivalled expertise and outstanding quality laboratory consumable products, striving to consistently improve. Please do get in touch with any comments regarding the website, service, products, or anything else.
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Obeticholic Acid
Obeticholic acid (OCA) is a synthetic derivative of the endogenous primary bile acid, chenodeoxycholic acid, and is primarily used to treat liver and bile duct pathologies. It has been approved by the FDA for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA. OCA has also been studied for its potential use in treating non-alcoholic steatohepatitis (NASH).
The mechanism of action of OCA involves reducing hepatic exposure to bile acids, which limits the progression of cholangitic processes such as PBC and primary sclerosing cholangitis (PSC). OCA is a first-in-class agonist that selectively binds to the farnesoid X receptor (FXR). This leads to direct and indirect suppression of bile acid production in the liver and increased bile flow, resulting in reduced exposure of the liver to toxic levels of bile acids. This reduced exposure should clinically translate into decreased parenchymal liver injury caused by bile acids, leading to improved biochemical enzyme profiles and decreased disease progression of PBC.
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